Restoring the gut microbiota - Dr. Arnout Mieremet

There is evidence that disruptions in the gut flora may contribute to symptoms in ME/CFS. Normally, these bacteria help your body with important functions, such as producing substances that provide energy, supporting the immune system, and aiding in recovery. When the balance between these bacteria is disturbed, they are less able to perform these tasks effectively. However, little is known about how these disturbances arise or which treatments might help restore this balance.

In this project, researchers study the gut flora of people with ME/CFS using specialized laboratory models that simulate the gut microbiota. In these models, they test different interventions, such as adding beneficial bacteria (probiotics) or dietary fibers (prebiotics). For this study, stool samples are collected from people with ME/CFS as well as from healthy volunteers. Using two different models, the researchers examine how gut bacteria function and how the substances they produce influence the intestinal lining.

With this research, the scientists aim to better understand whether people with ME/CFS have disruptions in their gut bacteria. They also aim to identify which treatments may help restore balance in the gut. The results may provide insight into which treatments stimulate the production of important compounds by the gut flora and thereby support the restoration of gut health. This knowledge lays the foundation for developing personalized treatments that align more closely with the biological characteristics of individual patients.